Analytical Data
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Gene name
SHFM1
- Application
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Alternative Names
SEM1; C7orf76; DSS1; SHFDG1; SHFM1; 26S proteasome complex subunit SEM1; 26S proteasome complex subunit DSS1; Deleted in split hand/split foot protein 1; Split hand/foot deleted protein 1; Split hand/foot malformation type 1 protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P60896
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Expression Region
1-70 aa
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AA Sequence
MSEKKQPVDL GLLEEDDEFE EFPAEDWAGL DEDEDAHVWE DNWDDDNVED DFSNQLRAEL EKHGYKMETS
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Molecular Weight
8.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SHFM1 (Split-Hand/Foot Malformation 1) is a genetically inherited condition characterized by the absence or malformation of digits in the hands and feet. The SHFM1 gene, located on chromosome 7, encodes a protein involved in the development of limb and digit formation during embryogenesis. Research into SHFM1 recombinant protein has gained traction due to its potential to unveil the molecular mechanisms underlying limb malformations. Understanding the structure and function of the SHFM1 protein can provide insights into its role in skeletal development and differentiation. As various mutations in the SHFM1 gene have been implicated in the condition, recombinant versions of the protein can help identify the specific mechanisms by which these mutations disrupt normal development. Additionally, studies utilizing SHFM1 recombinant protein may facilitate the identification of interacting partners and downstream signaling pathways, opening avenues for therapeutic interventions. Exploring the applications of SHFM1 protein in regenerative medicine and genetic counseling could lead to improved management strategies for affected individuals and offer valuable insights into the broader field of limb development and congenital malformations. Overall, investigating the SHFM1 recombinant protein serves as a crucial step in dissecting the genetic basis of limb formation and enhancing our understanding of associated abnormalities.
