Analytical Data
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基因名
FGFR1
- Application
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别名
FGFR1；BFGFR；CEK；FGFBR；Fibroblast growth factor receptor 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11362
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表达区间
22-376aa
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氨基酸序列
RPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGV QLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDA LPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAA KTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVV PSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGS NVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDK EMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTS PLYLE
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分子量
39 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Fibroblast growth factor receptor 1 (FGFR1) is a critical member of the fibroblast growth factor receptor family, which plays a vital role in various biological processes, including cell growth, differentiation, and tissue repair. Dysregulation of FGFR1 signaling is implicated in numerous pathological conditions, particularly various cancers, making it a significant target for therapeutic intervention. Research has focused on the development of recombinant FGFR1 proteins to better understand its structure, function, and interaction with ligands. These studies enable the elucidation of FGFR1's role in cellular pathways and its contribution to oncogenesis and developmental disorders. The expression and purification of FGFR1 as a recombinant protein facilitate detailed biochemical and biophysical characterization, paving the way for drug discovery and the design of FGFR inhibitors. Furthermore, insights gained from FGFR1 studies can contribute to the development of targeted therapies, enhancing precision medicine approaches for cancer treatment and improving clinical outcomes for patients. Thus, FGFR1 recombinant protein research is crucial for advancing our understanding of its biological significance and therapeutic potential.
