Analytical Data
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基因名
COX6B2
- Application
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别名
COX6B2Cytochrome c oxidase subunit 6B2; Cancer/testis antigen 59; CT59; Cytochrome c oxidase subunit VIb isoform 2; COX VIb-2; Cytochrome c oxidase subunit VIb; testis-specific isoform
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6YFQ2
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表达区间
1-88aa
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氨基酸序列
MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYFRVYHSLCPISWVESWNEQIKNGIFAGKI
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分子量
36.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
COX6B2, a crucial subunit of the cytochrome c oxidase (COX) complex, plays an essential role in mitochondrial respiratory function and cellular energy metabolism. This protein is integral to the electron transport chain, facilitating ATP production through oxidative phosphorylation. Dysregulation or mutations in COX6B2 can lead to mitochondrial dysfunction, which has been implicated in various neurodegenerative diseases and metabolic disorders. Recent research has focused on the structural and functional characterization of COX6B2, revealing its significance in maintaining COX stability and activity. Notably, studies have shown that alterations in COX6B2 expression levels can influence mitochondrial dynamics, bioenergetics, and apoptotic pathways. Given its vital role in energy metabolism, COX6B2 represents a potential therapeutic target for restoring mitochondrial function in disease contexts. As a result, researchers are increasingly investigating the biochemical properties and regulatory mechanisms of COX6B2, aiming to uncover novel insights into its role in health and disease. Understanding the complete functional landscape of COX6B2 is pivotal for developing strategies to mitigate the impact of mitochondrial-related diseases and enhancing overall cellular viability.
