Analytical Data
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Gene name
SLC24A6
- Application
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Alternative Names
FLJ22233 ; Na(+)/K(+)/Ca(2+) exchange protein 6; Na(+)/K(+)/Ca(2+)-exchange protein 6; NCKX6; NCKX6_HUMAN; NCLX ; Slc24a6; Sodium/potassium/calcium exchanger ; Sodium/potassium/calcium exchanger 6; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6 ; Solute carrier family 24 member 6
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6J4K2
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Expression Region
1-584 aa
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AA Sequence
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLNVSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
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Molecular Weight
90.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SLC24A6, a member of the solute carrier family 24, encodes a Na+/Ca2+/K+ exchanger predominantly expressed in the retina and brain. Its role in ion transport is critical for maintaining calcium homeostasis and neuronal signaling. Mutations in SLC24A6 have been linked to various disorders, including retinal diseases like congenital stationary night blindness and neurological conditions such as intellectual disability. The study of SLC24A6 recombinant protein is essential for elucidating its functional mechanisms and understanding the pathophysiology of associated diseases. By expressing and purifying the SLC24A6 protein in various systems, researchers can investigate its ion exchange activity, substrate specificity, and regulatory mechanisms. Characterization of this protein may also facilitate the development of targeted therapies aimed at correcting the ion transport dysregulation seen in SLC24A6-related disorders. Furthermore, understanding its structure-function relationship could provide insights into the design of small molecules that modulate its activity, potentially leading to novel therapeutic strategies for conditions linked to ion transport dysregulation. This research is crucial not only for the understanding of basic cellular processes but also for advancing medical science in treating retinal and neurological disorders associated with SLC24A6 dysfunction.
