Analytical Data
-
基因名
BMF
- Application
-
别名
BMF；Bcl-2-modifying factor
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q96LC9
-
表达区间
1-184aa
-
氨基酸序列
MEPSQCVEELEDDVFQPEDGEPVTQPGSLLSADLFAQSLLDCPLSRLQLFPLTHCCGPGLRPTSQEDKATQTLSPASPSPGVMLPCGVTEEPQRLFYGNAGYRLPLPASFPAVLPIGEQPPEGQWQHQAEVQIARKLQCIADQFHRLHVQQHQQNQNRVWWQILLFLHNLALNGEENRNGAGPR
-
分子量
47.5 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BMF (Bcl-2-modifying factor) is a pro-apoptotic protein that plays a significant role in regulating cell death and survival, particularly in the context of cancer. It functions by inhibiting the anti-apoptotic Bcl-2 family members, thus promoting apoptosis in cellular systems. The study of BMF and its recombinant protein form has gained importance due to its potential therapeutic implications in cancer treatment, considering that many cancers exploit the dysregulation of apoptotic pathways to evade cell death. Research has shown that BMF can sensitize cancer cells to chemotherapy by restoring the apoptotic response. Furthermore, variations in BMF expression levels have been implicated in various malignancies, linking its dysfunction to cancer progression and poor prognosis. The recombinant production of BMF allows for detailed studies on its structure-function relationships, interaction with other apoptotic proteins, and its role in cellular signaling pathways. This research is pivotal in developing novel cancer therapies targeted at modulating BMF activity, enhancing the efficacy of existing treatments, and ultimately improving patient outcomes. As such, understanding BMF at a molecular level could lead to breakthroughs in the design of strategies to manipulate apoptotic pathways in cancer therapy.
