Analytical Data
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基因名
GRIA4
- Application
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别名
GRIA4；GluA4；GLUR4；Glutamate receptor 4
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48058-2
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表达区间
1-433aa
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氨基酸序列
MRIISRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFL HNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDK RSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYE WNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEE LDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLE RFIHGGANVTGFQLVDFNTPMVIKLMDRWKKLDQREYPGSETPPKYTSAL TYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLK QVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQ DVPTLGNDTAAIENRTVVVTTIMPLMKNPILRN
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分子量
76 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRIA4, a member of the glutamate receptor ion channel family, plays a crucial role in synaptic transmission and plasticity in the central nervous system. This protein is predominantly expressed in the brain and is involved in mediating excitatory neurotransmission, contributing to various physiological processes including learning and memory. Research has identified GRIA4's significance in neurodevelopmental disorders and neurodegenerative diseases, highlighting its potential as a therapeutic target. However, the structural and functional characterization of GRIA4 has remained limited due to challenges in obtaining sufficient quantities of the recombinant protein. To overcome these barriers, efforts have been directed towards the successful expression and purification of GRIA4 in a heterologous system. Understanding the molecular mechanisms underlying GRIA4's function, along with the development of specific modulators, could pave the way for innovative treatment strategies for various brain disorders. This research aims not only to elucidate the functional properties of GRIA4 but also to explore its interactions with other proteins and ligands, providing insights into its regulatory mechanisms and potential implications in medical science.
