Analytical Data
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基因名
KRT35
- Application
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别名
KRT35；HHA5；HKA5；KRTHA5；Keratin. type I cuticular Ha5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q92764
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表达区间
1-455aa
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氨基酸序列
MASKCLKAGFSSGSLKSPGGASGGSTRVSAMYSSSSCKLPSLSPVARSFSACSVGLGRSSYRATSCLPALCLPAGGFATSYSGGGGWFGEGILTGNEKETMQSLNDRLAGYLEKVRQLEQENASLESRIREWCEQQVPYMCPDYQSYFRTIEELQKKTLCSKAENARLVVEIDNAKLAADDFRTKYETEVSLRQLVESDINGLRRILDDLTLCKSDLEAQVESLKEELLCLKKNHEEEVNSLRCQLGDRLNVEVDAAPPVDLNRVLEEMRCQYETLVENNRRDAEDWLDTQSEELNQQVVSSSEQLQSCQAEIIELRRTVNALEIELQAQHSMRDALESTLAETEARYSSQLAQMQCMITNVEAQLAEIRADLERQNQEYQVLLDVRARLECEINTYRGLLESEDSKLPCNPCAPDYSPSKSCLPCLPAASCGPSAARTNCSPRPICVPCPGGRF
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分子量
66.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRT35, or keratin 35, is a member of the keratin family, a group of fibrous structural proteins that are essential for the integrity and resilience of epithelial tissues. The research surrounding KRT35 has gained traction due to its potential roles in various physiological and pathological processes, including skin barrier function, epithelial cell integrity, and the development of certain diseases. Notably, mutations or dysregulation of keratin genes have been implicated in a range of skin disorders, such as epidermolysis bullosa, ichthyosis, and other keratinopathies. The exploration of KRT35 and its encoded protein, therefore, presents a promising avenue for understanding the molecular mechanisms underlying these conditions. Furthermore, KRT35 expression patterns may also offer insights into its involvement in cancer biology, as altered keratin expression is often observed in malignant tumors. By generating recombinant KRT35 proteins, researchers can conduct functional studies to elucidate its biological roles, interactions with other cellular components, and potential therapeutic applications. Such investigations could lead to the development of novel diagnostic markers or treatment strategies for keratin-associated diseases, advancing our understanding of epithelial biology and its implications for human health.
