Analytical Data
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基因名
DBNL
- Application
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别名
ABP1; Actin-binding protein 1; Cervical mucin associated protein; Cervical mucin-associated protein; Cervical SH3P7; CMAP; Dbnl; DBNL_HUMAN; Drebrin F; drebrin like; Drebrin like protein; Drebrin-F; Drebrin-like protein; HIP 55; HIP-55
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UJU6
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表达区间
1-430aa
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氨基酸序列
MAANLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEEMVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACASHVSTMASFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESGRFQDVGPQAPVGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRADLPAEEPAPSTPPCLVQAEEEAVYEEPPEQETFYEQPPLVQQQGAGSEHIDHHIQGQGLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
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分子量
73.04 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DBNL, or Dbl homology and PH domain-containing protein 1, plays a pivotal role in cellular signaling and actin cytoskeleton dynamics, making it a critical focus in the study of various physiological and pathological processes. Research has shown that DBNL is involved in the regulation of Rho GTPases, which are integral to controlling cell shape, motility, and proliferation. Dysregulation of DBNL has been implicated in several diseases, including cancer and neurological disorders. As a result, understanding the structure and function of DBNL, particularly in its ability to mediate protein-protein interactions and signaling pathways, is crucial for elucidating its role in health and disease. Recent advances in protein recombination techniques have facilitated the in-depth analysis of DBNL’s structure-function relationship, offering insights into its binding mechanisms and the molecular basis of its interactions with other signaling molecules. This knowledge not only enhances our understanding of DBNL's biological significance but also paves the way for potential therapeutic interventions targeting the pathways in which it is involved. The exploration of DBNL recombination proteins thus represents a promising avenue in molecular biology, with implications for drug development and the treatment of DBNL-related conditions.
