Analytical Data
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基因名
SNX12
- Application
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别名
SNX12
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UMY4
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表达区间
2-172 aa
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氨基酸序列
SDTAVADTRRLNSKPQDLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNELERDSKIVVPPLPGKALKRQLPFRGDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAIDRNYVPGKSLAVSCPGWSAVA
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分子量
24.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SNX12, a member of the sorting nexin family, plays a crucial role in intracellular trafficking and membrane dynamics. Research on SNX12 has garnered attention due to its involvement in various cellular processes, including endosomal sorting and vesicular transport, which are essential for maintaining cellular homeostasis. It has been implicated in the regulation of receptor recycling and degradation, impacting signaling pathways related to growth and differentiation. Understanding the functional mechanisms of SNX12 is also significant in the context of disease, as dysregulation of trafficking pathways can lead to conditions such as cancer and neurodegenerative disorders. By studying the recombinant SNX12 protein, researchers aim to elucidate its structural properties and interactions with other cellular partners, which may provide insights into the underlying mechanisms of diseases associated with cellular transport dysfunction. The production of recombinant SNX12 protein allows for detailed biochemical and biophysical characterizations, facilitating the exploration of its role in endosomal pathways and potential therapeutic applications. This research could contribute to the development of novel strategies targeting SNX12-related pathways in various diseases, highlighting its importance in both basic and applied biomedical research.
