Analytical Data
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基因名
HAO2
- Application
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别名
HAO2；HAOX2；2-Hydroxyacid oxidase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYQ3
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表达区间
2-351aa
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氨基酸序列
SLVCLTDFQAHAREQLSKSTRDFIEGGADDSITRDDNIAAFKRIRLRPRY LRDVSEVDTRTTIQGEEISAPICIAPTGFHCLVWPDGEMSTARAAQAAGI CYITSTFASCSLEDIVIAAPEGLRWFQLYVHPDLQLNKQLIQRVESLGFK ALVITLDTPVCGNRRHDIRNQLRRNLTLTDLQSPKKGNAIPYFQMTPIST SLCWNDLSWFQSITRLPIILKGILTKEDAELAVKHNVQGIIVSNHGGRQL DEVLASIDALTEVVAAVKGKIEVYLDGGVRTGNDVLKALALGAKCIFLGR PILWGLACKGEHGVKEVLNILTNEFHTSMALTGCRSVAEINRNLVQFSRL
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分子量
55 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HAO2 (Hydroxyacid oxidase 2) is an essential enzyme involved in various metabolic processes, particularly in ammonia oxidation and the regulation of cellular reactive oxygen species. Research into HAO2 has gained prominence due to its implications in both fundamental biology and potential therapeutic applications. The enzyme participates in the enzymatic pathway that converts L-amino acids into keto acids while producing hydrogen peroxide as a byproduct. This enzymatic activity is crucial for maintaining metabolic homeostasis. Moreover, dysregulation of HAO2 has been correlated with various diseases, including metabolic disorders and certain malignancies. Understanding the structure-function relationship of HAO2 can provide insights into its role in cellular metabolism and its potential as a target for drug development. Recent studies have utilized advanced techniques such as X-ray crystallography and molecular dynamics simulations to elucidate the enzyme's mechanism and substrate specificity. Identifying small molecules that can modulate HAO2 activity is an ongoing research focus, as such compounds could serve as novel therapeutic agents. Overall, the study of HAO2 is significant for comprehending metabolic pathways and offers potential avenues for medical intervention in disease contexts where HAO2 plays a critical role.
