Analytical Data
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基因名
DIRC2
- Application
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别名
SLC49A4; DIRC2Solute carrier family 49 member 4; Disrupted in renal cancer protein 2; Disrupted in renal carcinoma protein 2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96SL1
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表达区间
1-478aa
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氨基酸序列
MGSRWSSEEERQPLLGPGLGPGLGASWRSREAAAAALPAAVPGPGRVYGRRWLVLLLFSLLAFVQGLVWNTWGPIQNSARQAYGFSSWDIALLVLWGPIGFLPCFAFMWLLDKRGLRITVLLTSFLMVLGTGLRCIPISDLILKRRLIHGGQMLNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTSPLLAAESSRAHIKDRIEAVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSVCRLLSNFRFLMIALAYAIPLGVFAGWSGVLDLILTPAHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFLTFYHTELSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV
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分子量
78.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DIRC2 (Diffusely Inherited Renal Cell Carcinoma 2) is an important protein that has gained attention in cancer research, particularly in relation to renal cell carcinoma (RCC). With the rising incidence and mortality rates associated with RCC globally, understanding the molecular mechanisms underlying this cancer type has become increasingly urgent. DIRC2 is believed to play a significant role in tumorigenesis and cancer progression, particularly as it has been implicated in cellular processes such as proliferation, differentiation, and apoptosis. Recent studies suggest that alterations in the expression levels of DIRC2 may contribute to the oncogenic pathways in RCC, potentially serving as a biomarker for diagnosis or prognosis. Furthermore, the protein's involvement in key signaling pathways makes it a promising target for therapeutic intervention. As such, research efforts are focused on elucidating the precise functions of DIRC2 in cancer biology, exploring its interactions with other molecules, and assessing its potential as a therapeutic target or biomarker to improve patient outcomes in renal cell carcinoma. As advancements in genomic technologies and proteomics continue to evolve, the understanding of DIRC2's role in RCC may lead to innovative strategies for early detection, personalized treatment approaches, and improved survival rates for affected individuals.
