Cat: PA1000-7911

Recombinant Human SLFN5 Protein,His

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Analytical Data

  • Gene name

    SLFN5

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    SLFN5;Schlafen family member 5

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q6IEE8

  • Expression Region

    1-588aa

  • AA Sequence

    MDLARKEFLRGNGLAAGKMNISIDLDTNYAELVLNVGRVTLGENNRKKMK DCQLRKQQNENVSRAVCALLNSGGGVIKAEVENKGYSYKKDGIGLDLENS FSNMLPFVPNFLDFMQNGNYFHIFVKSWSLETSGPQIATLSSSLYKRDVT SAKVMNASAALEFLKDMEKTGGRAYLRPEFPAKRACVDVQEESNMEALAA DFFNRTELGYKEKLTFTESTHVEIKNFSTEKLLQRITEILPQYVSAFANT DGGYLFVGLNEDKEVIGFKAEKSYLTKLEEVTKNSIGKLPVHHFCVEKGT INYLCKFLGVYDKGRLCGYVYALRVERFCCAVFAKKPDSWHVKDNRVKQL TEKEWIQFMVDSEPVCEELPSPASTSSPVSQSYPLREYINFKIQPLRYHL PGLSEKITCAPKTFCRNLFSQHEGLKQLICEEMGSVNKGSLIFSRSWSLD LGLQENHKVLCDALLISQDKPPVLYTFHMVQDEEFKDYSTQTAQTLKQKL AKIGGYTKKVCVMTKIFYLSPEGKTSCQYDLNSQVIYPESYYWTTAQTMK DLEKALSNILPKENQIFLFVCLFRFCLFVCWFVCFFLR

  • Molecular Weight

    72 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

SLFN5 (Sleeping Beauty Factor 5) is a member of the Schlafen family of proteins, which are implicated in various biological processes, including cell proliferation, differentiation, and immune response modulation. Research into SLFN5 has gained traction due to its potential roles in cancer biology and viral infections, particularly its association with modulating the immune response in cancer cells. As a repressive transcription factor, SLFN5 has been shown to interact with various signaling pathways, influencing gene expression and cellular behavior. Additionally, studies indicate that SLFN5 may play a critical role in the regulation of antiviral responses, highlighting its importance in both tumor biology and host-pathogen interactions. The recombinant protein form of SLFN5 offers a valuable tool for investigating its functional properties, interactions, and downstream effects in cellular contexts. By expressing and purifying SLFN5 as a recombinant protein, researchers can conduct detailed biochemical and biophysical analyses, ultimately leading to a better understanding of its mechanisms of action and potential therapeutic applications. Continued exploration of SLFN5 and its pathways could open new avenues for targeted therapies in cancer treatment and enhanced strategies for combating viral diseases.

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