Analytical Data
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Gene name
TAK1L
- Application
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Alternative Names
TAK1L；C21orf7；TAK1L；MAP3K7 C-terminal-like Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43318-2
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Expression Region
1-579aa
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AA Sequence
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVV CKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIVKLYGACLNPV CLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPK ALIHRDLKPPNLLLVAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEV FEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPP LIKNLPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQY PCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLES KLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIA ATTGNGQPRRRSIQDLTVTGTEPGQVSSRSSSPSVRMITTSGPTSEKPTR SHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPLAPCPNSKESMAVFEQHC KMAQEYMKVQTEIALLLQRKQELVAELDQDEKDQQNTSRLVQEHKKLLDE NKSLSTYYQQCKKQLEVIRSQQQKRQGTS
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Molecular Weight
89 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TAK1L (Transforming Growth Factor Beta-Activated Kinase 1 Homolog) is a member of the TAK1 family of serine/threonine kinases, which plays a critical role in various cellular processes, including inflammation, apoptosis, and cell proliferation. The study of TAK1L has gained significant attention due to its potential involvement in signaling pathways that regulate immune responses and cellular stress. Research has shown that TAK1L participates in the activation of different transcription factors, thus influencing gene expression in response to cytokines and stressors. The recombinant protein production of TAK1L enables researchers to investigate its functional properties, interactions with other proteins, and overall role in disease mechanisms, particularly in contexts such as cancer and autoimmune diseases. Furthermore, recombinant TAK1L can be utilized as a tool for drug discovery and development, providing insights into targeted therapies that could modulate its pathway. Given the essential functions of TAK1L in cellular signaling, understanding its mechanisms at the molecular level could lead to novel therapeutic strategies and enhance our knowledge of its biological significance. As such, the study of TAK1L recombinant proteins forms a crucial foundation for advancing our understanding of complex biological processes and developing innovative medical interventions.
