Analytical Data
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Gene name
TBX19
- Application
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Alternative Names
TBX19; TPIT; T-box transcription factor TBX19; T-box protein 19; T-box factor; pituitary
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60806
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Expression Region
1-448 aa
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AA Sequence
MAMSELGTRK PSDGTVSHLL NVVESELQAG REKGDPTEKQ LQIILEDAPL WQRFKEVTNE MIVTKNGRRM FPVLKISVTG LDPNAMYSLL LDFVPTDSHR WKYVNGEWVP AGKPEVSSHS CVYIHPDSPN FGAHWMKAPI SFSKVKLTNK LNGGGQIMLN SLHKYEPQVH IVRVGSAHRM VTNCSFPETQ FIAVTAYQNE EITALKIKYN PFAKAFLDAK ERNHLRDVPE AISESQHVTY SHLGGWIFSN PDGVCTAGNS NYQYAAPLPL PAPHTHHGCE HYSGLRGHRQ APYPSAYMHR NHSPSVNLIE SSSNNLQVFS GPDSWTSLSS TPHASILSVP HTNGPINPGP SPYPCLWTIS NGAGGPSGPG PEVHASTPGA FLLGNPAVTS PPSVLSTQAP TSAGVEVLGE PSLTSIAVST WTAVASHPFA GWGGPGAGGH HSPSSLDG
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Molecular Weight
48.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TBX19, also known as T-box transcription factor 19, plays a crucial role in the development and function of the pituitary gland, particularly in regulating the expression of genes involved in the synthesis and secretion of adrenocorticotropic hormone (ACTH). The study of TBX19 has gained significant attention due to its association with various endocrine disorders, including congenital adrenal hyperplasia and Nelson's syndrome, where dysregulation of ACTH leads to adrenal dysfunction. As a transcription factor, TBX19 interacts with specific DNA sequences to facilitate the transcription of target genes, making its recombinant protein an essential tool for elucidating its regulatory mechanisms. Researchers have been focusing on the characterization of recombinant TBX19 proteins to better understand their functional roles in cellular processes and their implications in disease. The production of TBX19 as a recombinant protein allows for in vitro studies, including investigations into protein-protein interactions, post-translational modifications, and the overall impact of TBX19 on gene expression profiles. Furthermore, the development of assays utilizing TBX19 recombinant protein can advance the understanding of its biological functions and pave the way for novel therapeutic approaches targeting TBX19-related pathologies. Overall, the exploration of TBX19 recombinant protein is vital for advancing knowledge in endocrine signaling and could lead to significant breakthroughs in treating disorders linked with altered TBX19 function.
