Analytical Data
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Gene name
ZDHHC1
- Application
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Alternative Names
ZDHHC1; C16orf1; ZNF377; Palmitoyltransferase ZDHHC1; DHHC domain-containing cysteine-rich Protein 1; Zinc finger DHHC domain-containing Protein 1; DHHC-1; Zinc finger Protein 377
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WTX9
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Expression Region
1-485 aa
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AA Sequence
MYKMNICNKPSNKTAPEKSVWTAPAQPSGPSPELQGQRSRRNGWSWPPHPLQIVAWLLYLFFAVIGFGILVPLLPHHWVPAGYACMGAIFAGHLVVHLTAVSIDPADANVRDKSYAGPLPIFNRSQHAHVIEDLHCNLCNVDVSARSKHCSACNKCVCGFDHHCKWLNNCVGERNYRLFLHSVASALLGVLLLVLVATYVFVEFFVNPMRLRTNRHFEVLKNHTDVWFVFLPAAPVETQAPAILALAALLILLGLLSTALLGHLLCFHIYLMWHKLTTYEYIVQHRPPQEAKGVHRELESCPPKMRPIQEMEFYMRTFRHMRPEPPGQAGPAAVNAKHSRPASPDPTPGRRDCAGPPVQVEWDRKKPLPWRSPLLLLAMWGPQAPPCLCRKRGRGACIKCERLRPRIRRRGLGPPAAAPARRRIPRTPALCTPLALPAPTTRRRQSPWTRFQWRRRAWAAPLWPPRGAGADSPRWRGRRVRPPFS
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Molecular Weight
81.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ZDHHC1 is a member of the zinc finger DHHC-type palmitoyltransferase (ZDHHC) family, which is crucial for the post-translational modification known as palmitoylation. This modification involves the addition of palmitic acid to cysteine residues within proteins, influencing their membrane localization, stability, and function. Research on ZDHHC1 has garnered interest due to its potential role in various cellular processes, including signal transduction, protein trafficking, and tumorigenesis. Notably, mutations in the ZDHHC1 gene have been associated with certain neurological disorders, highlighting its significance in neural development and function. The study of ZDHHC1 recombinant proteins allows researchers to investigate the enzyme's substrate specificity, kinetics, and the structural basis for its enzymatic activity. Additionally, understanding how ZDHHC1 interacts with specific proteins could unveil new therapeutic targets for diseases linked to impaired palmitoylation. Given its implications in various biological functions and diseases, ZDHHC1 stands as a promising candidate for further exploration in both basic and translational research.
