Analytical Data
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基因名
TMED4
- Application
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别名
Endoplasmic reticulum stress-response Protein 25; ERS25; GMP25iso; HNLF; p24 family Protein alpha-3; p24alpha3; Putative NF-kappa-B-activating Protein 156; Putative NFkB activating Protein HNLF; TMED4; TMED4_HUMAN; Transmembrane emp24 domain containing Protein 4; Transmembrane emp24 domain-containing Protein 4; Transmembrane emp24 Protein transport domain containing 4
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z7H5
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表达区间
1-227 aa
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氨基酸序列
MAGVGAGPLRAMGRQALLLLALCATGAQGLYFHIGETEKRCFIEEIPDETMVIGNYRTQMWDKQKEVFLPSTPGLGMHVEVKDPDGKVVLSRQYGSEGRFTFTSHTPGDHQICLHSNSTRMALFAGGKLRVHLDIQVGEHANNYPEIAAKDKLTELQLRARQLLDQVEQIQKEQDYQRYREERFRLTSESTNQRVLWWSIAQTVILILTGIWQMRHLKSFFEAKKLV
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分子量
52.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMED4, also known as transmembrane emp20 domain-containing protein 4, is a member of the TMED family, which plays a crucial role in the transport and sorting of proteins within the secretory pathway. Research on TMED4 has gained significance due to its involvement in various cellular processes, including protein glycosylation and the regulation of endoplasmic reticulum-associated degradation (ERAD). Aberrant expression of TMED4 has been linked to several pathological conditions, including cancer and neurodegenerative disorders, highlighting its potential as a biomarker and therapeutic target. The recombinant expression of TMED4 in model systems facilitates the study of its structural and functional properties, advancing our understanding of its role in cellular homeostasis and the mechanisms underlying disease. Characterizing recombinant TMED4 can provide insights into its interaction with other proteins, elucidating its specific contributions to intracellular trafficking. Furthermore, the generation of recombinant TMED4 may enable the development of novel pharmacological interventions aimed at modulating its function, ultimately paving the way for innovative treatment strategies in diseases linked to protein misfolding and trafficking anomalies. These aspects underscore the relevance of TMED4 in both basic and applied biomedical research, making it a compelling subject for further investigation.
