Analytical Data
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基因名
CASP8AP2
- Application
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别名
CASP8AP2;FLASH;KIAA1315;RIP25;CASP8-associated Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKL3
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CASP8AP2, also known as caspase-8 associated protein 2, is a protein that plays a critical role in regulating apoptosis and cellular stress responses. Research has shown that CASP8AP2 interacts with caspase-8, a key enzyme in the apoptosis signaling pathway, suggesting a significant function in modulating cell death and survival. Understanding the function of CASP8AP2 is vital due to its potential implications in various pathological conditions, including cancer, neurodegenerative disorders, and autoimmune diseases, where dysregulation of apoptosis can lead to abnormal cell proliferation or death. Recent studies have focused on the recombinant expression of CASP8AP2 to investigate its structural and functional properties, enabling a deeper understanding of its role in apoptotic signaling. By producing recombinant CASP8AP2, researchers can analyze its interaction with caspase-8 and other associated proteins, providing insights into its mechanisms of action. This knowledge could pave the way for the development of novel therapeutic strategies aimed at targeting apoptosis-related pathways in diseases characterized by impaired cell death. Furthermore, the ability to manipulate CASP8AP2 levels can enhance our understanding of cellular stress responses and their implications for disease progression, making it a target of significant interest in biomedical research. Overall, the exploration of recombinant CASP8AP2 not only contributes to the fundamental understanding of apoptosis but also holds promise for therapeutic advancements in diseases where apoptosis plays a crucial role.












