Cat: PA1000-8484

Recombinant Human CASP6 Protein,His

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Analytical Data

  • 基因名

    CASP6

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    CASP6;MCH2;Caspase-6

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    His tag N-Terminus

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    P55212

  • 表达区间

    24-179aa

  • 氨基酸序列

    AFYKREM FDPAEKYKMD HRRRGIALIF NHERFFWHLT LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI HEVSTVSHAD ADCFVCVFLS HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS LVGKPKIFII QACRGNQHDV PVIPLDVVD

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

CASP6, or caspase-6, is a crucial enzyme in the apoptosis pathway, playing an essential role in programmed cell death and influencing various physiological processes such as neuronal development and immune response. Dysregulation of CASP6 has been implicated in several neurodegenerative diseases, including Alzheimer's disease, where increased caspase activity is associated with neurodegeneration and cognitive decline. Research on recombinant CASP6 proteins has gained traction due to their potential therapeutic applications and the need to understand their specific functional mechanisms in cellular processes. By producing CASP6 in a recombinant form, researchers can overcome difficulties related to natural protein extraction, allowing for more controlled studies and the examination of substrate interactions, enzyme kinetics, and inhibitor screening. Additionally, studying CASP6 in detail may lead to the identification of novel biomarkers for disease progression or targets for pharmacological intervention, particularly in the context of neurodegeneration. This research not only enhances the understanding of programmed cell death but also paves the way for developing new strategies to tackle diseases associated with aberrant apoptotic signaling. Overall, the study of recombinant CASP6 proteins contributes significantly to the field of molecular biology and holds promise for advancing therapeutic approaches in neurodegenerative conditions.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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