Analytical Data
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基因名
FBXO25
- Application
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别名
F box only protein 25; F box protein 25; F box protein Fbx25; F-box only protein 25; FBX25 ; FBX25_HUMAN; FBXO25; MGC20256
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TCJ0
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表达区间
1-367aa
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氨基酸序列
MPFLGQDWRSPGWSWIKTEDGWKRCESCSQKLERENNHCNISHSIILNSEDGEIFNNEEHEYASKKRKKDHFRNDTNTQSFYREKWIYVHKESTKERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVKLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLDDHHNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETILAWQQQLQDLQMTKQVNNGLTLSDLPLHMLNNILYRFSDGWDIITLGQVTPTLYMLSEDRQLWKKLCQYHFAEKQFCRHLILSEKGHIEWKLMYFALQKHYPAKEQYGDTLHFCRHCSILFWKDYHLALLFKDSGHPCTAADPDSCFTPVSPQHFIDLFKF
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分子量
66.11 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FBXO25 is a member of the F-box protein family, which plays crucial roles in the ubiquitin-proteasome pathway, a key cellular mechanism for protein degradation and turnover. Research into FBXO25 has gained prominence due to its involvement in various biological processes, including cell cycle regulation, apoptosis, and signal transduction. Dysregulation of FBXO25 has been implicated in several diseases, particularly cancer, where altered protein degradation can lead to uncontrolled cell proliferation and tumor progression. Understanding the functional mechanisms of FBXO25 and its interactions with other cellular components is essential for elucidating its role in these processes. Furthermore, studies involving recombinant FBXO25 protein allow for a detailed exploration of its structure-function relationships, potential post-translational modifications, and interactions with target proteins. This research could also unveil new therapeutic targets, as manipulating FBXO25 activity may offer novel strategies for cancer treatment and other diseases linked to proteostasis imbalances. Consequently, the study of recombinant FBXO25 is pivotal for both basic biological understanding and potential clinical applications.
