Analytical Data
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基因名
UBXD3
- Application
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别名
UBX domain-containing Protein 10. UBX domain-containing Protein 3
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96LJ8
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表达区间
1-280 aa
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氨基酸序列
MATEAPVNIAPPECSTVVSTAVDSLIWQPNSLNMHMIRPKSAKGRTRPSLQKSQGVEVCAHHIPSPPPAIPYELPSSQKPGACAPKSPNQGASDEIPELQQQVPTGASSSLNKYPVLPSINRKNLEEEAVETVAKKASSLQLSSIRALYQDETGTMKTSEEDSRARACAVERKFIVRTKKQGSSRAGNLEEPSDQEPRLLLAVRSPTGQRFVRHFRPTDDLQTIVAVAEQKNKTSYRHCSIETMEVPRRRFSDLTKSLQECRIPHKSVLGISLEDGEGWP
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分子量
57.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBXD3, a member of the UBX protein family, is involved in various cellular processes, including protein degradation and membrane trafficking. It is characterized by its ability to interact with components of the ubiquitin-proteasome system, which plays a vital role in regulating protein turnover and maintaining cellular homeostasis. The interest in UBXD3 has increased due to its potential implications in cancer biology and neurodegenerative diseases, where dysregulation of protein homeostasis can lead to pathological conditions. Research has shown that UBXD3 can inhibit certain E3 ubiquitin ligases, thereby influencing substrate degradation, and it may also modulate the activity of autophagy-related pathways. Furthermore, understanding the structural and functional properties of UBXD3 through recombinant protein studies can provide insights into its specific roles in cellular signaling and stress responses. The exploration of UBXD3 as a therapeutic target highlights the need for detailed characterization of its interactions and mechanisms of action, which may ultimately contribute to the development of novel strategies for treating diseases associated with protein misfolding and aggregation. Therefore, producing and analyzing recombinant UBXD3 is essential for unraveling its biological functions and therapeutic potential.
