Analytical Data
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Gene name
ADNP
- Application
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Alternative Names
ADNP；ADNP1；KIAA0784；Activity-dependent neuroprotector homeobox Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H2P0
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ADNP (Activity-Dependent Neuroprotective Protein) is a crucial protein implicated in neurodevelopment and neuroprotection, garnering attention for its role in various neurological disorders. Initially identified as a transcription factor that regulates gene expression in response to neuronal activity, ADNP is found to be involved in critical processes such as synaptic plasticity, neuronal survival, and cognitive function. Research has demonstrated that mutations in the ADNP gene can lead to neurodevelopmental disorders, including intellectual disabilities and autism spectrum disorders, highlighting its significance in brain health. Additionally, ADNP has been linked to the regulation of tau phosphorylation, suggesting a potential connection to neurodegenerative diseases such as Alzheimer's. Studies exploring the functions of ADNP have uncovered its role in promoting neuronal differentiation and survival under stress conditions, further emphasizing its therapeutic potential. The development of ADNP recombinant proteins for research purposes aims to elucidate the intricate mechanisms by which ADNP exerts its neuroprotective effects, paving the way for innovative interventions in treating and preventing neurological disorders. As the field of neuroscience continues to advance, ADNP stands out as a promising target for future research, with the potential to revolutionize our understanding of brain development and disease.
