Recombinant Human HTT Protein，His

HTT (Huntingtin) is a protein encoded by the HTT gene, which plays a critical role in neuronal function and development. Research into HTT has gained significant attention due to its association with Huntington's disease, a hereditary neurodegenerative disorder characterized by motor dysfunction, cognitive decline, and psychiatric symptoms. The pathogenesis of Huntington's disease is linked to the expansion of CAG repeats in the HTT gene, leading to the production of a mutant form of the protein. This mutant HTT is known to aggregate within neurons, disrupting cellular functions and triggering apoptotic pathways. Studies have focused on elucidating the molecular mechanisms by which mutant HTT exerts its toxic effects, exploring its interactions with cellular machinery, including protein aggregation pathways, mitochondrial function, and synaptic integrity. Furthermore, researchers are investigating potential therapeutic strategies aimed at reducing mutant HTT levels, such as gene silencing approaches and small molecules that can modulate its activity. Understanding the structure and function of HTT is vital for developing effective interventions to combat the progression of Huntington's disease, providing insight into not only its pathophysiology but also broader implications for neurodegeneration.