Analytical Data
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Gene name
TRAM1
- Application
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Alternative Names
TRAM1；TRAM；Translocating chain-associated membrane Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15629
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Expression Region
1-374aa
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AA Sequence
MAIRKKSTKSPPVLSHEFVLQNHADIVSCVAMVFLLGLMFEITAKASIIF VTLQYNVTLPATEEQATESVSLYYYGIKDLATVFFYMLVAIIIHAVIQEY MLDKINRRMHFSKTKHSKFNESGQLSAFYLFACVWGTFILISENYISDPT ILWRAYPHNLMTFQMKFFYISQLAYWLHAFPELYFQKTKKEDIPRQLVYI GLYLFHIAGAYLLNLNHLGLVLLVLHYFVEFLFHISRLFYFSNEKYQKGF SLWAVLFVLGRLLTLILSVLTVGFGLARAENQKLDFSTGNFNVLAVRIAV LASICVTQAFMMWKFINFQLRRWREHSAFQAPAVKKKPTVTKGRSSKKGT ENGVNGTLTSNVADSPRNKKEKSS
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TRAM1 (Translocating Chain-Associated Membrane Protein 1) is a crucial protein involved in the translocation process of polypeptides across the endoplasmic reticulum (ER) membrane, playing a vital role in protein synthesis and maturation. Research on TRAM1 has gained significance due to its implications in various biological processes and diseases, including cancer and neurodegenerative disorders. Studies have shown that TRAM1 functions in the recognition and integration of nascent polypeptides into the ER membrane, which is essential for proper protein folding and eventual trafficking to their functional destinations. The understanding of TRAM1's structure and function is critical for deciphering the mechanisms underlying protein translocation and for developing therapeutic strategies targeting related pathologies. Recent advances in recombinant protein technology have facilitated the study of TRAM1, allowing researchers to produce and characterize this protein in vitro. Investigating TRAM1 through recombinant methods not only enhances our comprehension of its biological roles but also provides insights into its potential as a drug target. Overall, TRAM1 stands at the intersection of molecular biology and therapeutic development, making it a focal point for ongoing research in the field of cellular biology.
