Analytical Data
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基因名
GFI1
- Application
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别名
GFI 1; GFI1; GFI1_HUMAN; Growth factor independence 1; Growth factor independent 1; Growth factor independent protein 1; SCN2; Zinc finger protein 163; Zinc finger protein Gfi 1; Zinc finger protein Gfi-1; Zinc finger protein Gfi1; ZNF 163; ZNF163
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99684
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表达区间
1-422aa
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氨基酸序列
MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE NVPAPSRADS TSNAGGAKAE PRDRLSPESQ LTEAPDRASA SPDSCEGSVC ERSSEFEDFW RPPSPSASPA SEKSMCPSLD EAQPFPLPFK PYSWSGLAGS DLRHLVQSYR PCGALERGAG LGLFCEPAPE PGHPAALYGP KRAAGGAGAG APGSCSAGAG ATAGPGLGLY GDFGSAAAGL YERPTAAAGL LYPERGHGLH ADKGAGVKVE SELLCTRLLL GGGSYKCIKC SKVFSTPHGL EVHVRRSHSG TRPFACEMCG KTFGHAVSLE QHKAVHSQER SFDCKICGKS FKRSSTLSTH LLIHSDTRPY PCQYCGKRFH QKSDMKKHTF IHTGEKPHKC QVCGKAFSQS SNLITHSRKH TGFKPFGCDL CGKGFQRKVD LRRHRETQHG LK
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分子量
45.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GFI1 (Growth Factor Independence 1) is a key transcription factor that plays a crucial role in hematopoiesis, neuronal development, and cell differentiation. Its function is primarily associated with the regulation of gene expression during these processes, making it a significant protein in both normal physiological and pathological states. Research has shown that GFI1 is involved in various cancers, particularly acute myeloid leukemia (AML), where its overexpression can contribute to tumorigenesis and the maintenance of leukemia stem cells. Understanding the structure and function of GFI1 through the study of its recombinant protein is essential for uncovering its mechanisms of action. This research could pave the way for potential therapeutic strategies targeting GFI1 in cancers or other diseases characterized by dysregulated hematopoiesis and development. By producing recombinant GFI1 proteins, scientists can explore its interactions with other cellular components, its regulatory networks, and the implications of post-translational modifications in its activity. Additionally, recombinant GFI1 can be a valuable tool for drug screening and development, as modulating its activity may yield innovative approaches to treat related conditions. Overall, the study of GFI1 recombinant protein not only enhances our understanding of its biological significance but also opens avenues for novel therapeutic interventions in hematological malignancies and neurodevelopmental disorders.
