Analytical Data
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基因名
NOTCH1
- Application
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别名
NOTCH1；TAN1；Neurogenic locus notch homolog Protein 1
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种属
Human
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表达系统
E. coli
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标签
N-terminal His Tag
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P46531
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表达区间
1-555aa
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氨基酸序列
MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVG PRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLT NPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASY ICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCE RPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGG ACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCV NGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACIS NPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINT LGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVH CEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNG AKCLDGPNTYTCVCT
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分子量
61.8kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
NOTCH1 is a critical receptor in the Notch signaling pathway, which plays a pivotal role in various biological processes, including cell differentiation, proliferation, and apoptosis. Dysregulation of NOTCH1 signaling has been implicated in several diseases, particularly cancer, where mutations or aberrant activation can contribute to tumorigenesis. Researchers have developed recombinant NOTCH1 proteins to investigate their structure-function relationships and the molecular mechanisms underlying NOTCH signaling. These recombinant proteins are essential for exploring the interactions with ligands and other signaling partners, providing insights into the pathway's modulation. Furthermore, understanding the biochemical properties and functional dynamics of NOTCH1 can inform therapeutic strategies, as targeting this pathway holds potential for treating cancers and other disorders associated with NOTCH dysregulation. The generation of recombinant NOTCH1 proteins facilitates high-throughput screenings and functional assays, paving the way for novel discoveries in both basic and applied biomedical research.
