Analytical Data
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基因名
MST1/STK4
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简介
MST1/STK4 protein is a stress-activated kinase that is critical in the Hippo signaling pathway and can induce apoptosis and regulate hepatocyte proliferation. Cleaved MST1/STK4 enters the nucleus, causing chromatin condensation and DNA fragmentation. MST1/STK4 Protein, Human (sf9, His) is the recombinant human-derived MST1/STK4 protein, expressed by Sf9 insect cells , with N-10*His labeled tag.
- Application
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别名
Serine/threonine-protein kinase 4; MST1/N; MST1/C; STK4; KRS2
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种属
Human
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表达系统
E.Coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13043
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表达区间
1-326aa
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分子量
37 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
MST1, also known as STK4, is a serine/threonine kinase that plays a crucial role in various cellular processes, including apoptosis, cell proliferation, and immune response. As a key component of the Hippo signaling pathway, MST1 is involved in regulating organ size and tissue growth by controlling cell division and promoting apoptosis in excess cells. Dysregulation of MST1 has been associated with various diseases, including cancer, where its reduced activity can lead to unchecked cell proliferation. Additionally, MST1 is implicated in the regulation of immune cell function and response, making it a potential therapeutic target in immunological disorders. Research on recombinant MST1/STK4 protein is essential for understanding its functional roles and mechanisms in cellular signaling pathways. By producing and studying this protein, scientists can dissect its interactions with other signaling molecules and further explore its potential as a target for drug development. The structure and activity of MST1 can be analyzed using various biochemical techniques, promoting the understanding of its role in health and disease. Overall, the investigation of MST1/STK4 recombinant protein contributes to a broader understanding of kinase signaling, cellular regulation, and the development of novel therapeutic strategies for diseases linked to its dysfunction.
