Analytical Data
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Gene name
Ccl3
- Application
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Alternative Names
Heparin-binding chemotaxis protein;L2G25BMacrophage inflammatory protein 1-alpha ;MIP-1-alpha;SIS-alpha;Small-inducible cytokine A3TY-5
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Species
Mouse
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Source
E. coli
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Tag
GST+His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P10855
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Expression Region
24-92aa
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Molecular Weight
37 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
Ccl3, also known as C-C motif chemokine 3 or macrophage inflammatory protein-1 alpha (MIP-1α), is a significant chemokine involved in immune response and inflammation. It primarily functions by recruiting monocytes, macrophages, and T-cells to sites of inflammation, playing a critical role in various pathological conditions, including chronic inflammatory diseases, infections, and tumor progression. Research on Ccl3 recombinant protein has gained traction due to its potential therapeutic applications, such as in the modulation of immune responses and the treatment of diseases where inflammation plays a key role. The production of Ccl3 as a recombinant protein allows for detailed studies on its structure, function, and interaction with receptors, providing insights into its mechanisms in immune regulation. Additionally, understanding its role in different biological contexts can lead to innovative strategies for therapeutic interventions. Recent studies have suggested that manipulating Ccl3 levels or its signaling pathways could enhance immune responses against tumors or regulate excessive inflammation. This growing body of research highlights the importance of Ccl3 recombinant protein in both fundamental immunology and clinical applications, making it a promising target for future therapeutic developments.
