Analytical Data
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Gene name
PPM1A
- Application
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Alternative Names
Protein phosphatase 2C isoform alpha
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35813
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Expression Region
1-382aa
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Molecular Weight
69.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPM1A (Protein Phosphatase, Mg2+/Mn2+ Dependent 1A) is a serine/threonine phosphatase that plays a critical role in various cellular processes, including cell cycle regulation, apoptosis, and stress responses. Research on PPM1A has gained momentum due to its involvement in several pathological conditions, such as cancer and cardiovascular diseases. PPM1A is known to dephosphorylate several key proteins, thereby modulating signaling pathways that are crucial for cell growth and survival. For instance, its activity can influence the MAPK/ERK signaling pathway, which is frequently dysregulated in tumors. Furthermore, PPM1A has been identified as a key regulator of the tumor suppressor p53 and the oncogene c-Myc, highlighting its potential as a therapeutic target in cancer treatment. The exploration of PPM1A recombinant protein enables researchers to delve deeper into its biochemical properties, regulatory mechanisms, and interaction with various substrates. By producing PPM1A in a recombinant expression system, scientists can obtain large quantities of the protein for functional studies, providing insights into its role in disease and aiding the development of novel therapeutic strategies. Overall, the ongoing research on PPM1A not only enhances our understanding of fundamental cellular processes but also opens new avenues for therapeutic intervention in diseases characterized by aberrant signaling pathways.
