Analytical Data
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Gene name
C-Reactive
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简介
C-Reactive Protein, an acute-phase protein, is a marker of inflammation and is produced by the liver. It is used as a diagnostic tool to assess the presence and severity of inflammation in various diseases. C-Reactive Protein's role in inflammation detection and its clinical significance in disease management make it a subject of interest in medical research. C-Reactive Protein, Human (HEK293) is the recombinant human-derived C-Reactive protein, expressed by HEK293 , with tag free.
- Application
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Alternative Names
C-Reactive Protein; CRP; PTX1
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Species
Human
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Source
HEK293
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P02741-1
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Expression Region
Q19-P224
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AA Sequence
QTDMSRKAFVFPKESDTSYVSLKAPLTKPLKAFTVCLHFYTELSSTRGYSIFSYATKRQDNEILIFWSKDIGYSFTVGGSEILFEVPEVTVAPVHICTSWESASGIVEFWVDGKPRVRKSLKKGYTVGAEASIILGQEQDSFGGNFEGSQSLVGDIGNVNMWDFVLSPDEINTIYLGGPFSPNVLNWRALKYEVQGEVFTKPQLWP
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Protein Length
Full Length of Isoform-1 Mature Protein
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Molecular Weight
26 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
S100A9, a member of the S100 protein family, is a calcium-binding protein that plays crucial roles in various biological processes, including inflammation, cell growth, and differentiation. Its expression is notably elevated in inflammatory conditions and various tumors, making it a potential biomarker for diseases like rheumatoid arthritis, cancer, and cardiovascular disorders. Research has shown that S100A9 participates in the regulation of immune responses by modulating the activity of immune cells, particularly neutrophils and monocytes. Additionally, it has been implicated in the formation of the S100A8/S100A9 complex, which exhibits pro-inflammatory properties and influences the tumor microenvironment. Given its significant involvement in pathophysiological conditions, S100A9 recombinant protein has gained attention as a research tool for studying its functional roles and therapeutic potential. The recombinant production of S100A9 allows for the investigation of its biological activities in vitro and in vivo, facilitating the exploration of targeted therapies aimed at mitigating inflammatory responses and tumor progression. Understanding the mechanisms by which S100A9 operates may lead to novel therapeutic strategies and enhance our knowledge of its implications in health and disease. Thus, ongoing research into S100A9 recombinant protein is vital for elucidating its functions and developing advanced diagnostic and therapeutic modalities.
