Analytical Data
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Gene name
DERP1
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简介
DERP1 Protein, a thiol protease, selectively cleaves target proteins with distinct structural features, favoring substrates with a large hydrophobic side chain in the P2 position or basic residues. This specificity underscores DERP1's functional significance in cellular processes. DERP1 Protein, Dermatophagoides pteronyssinus (C132A, N150E, HEK293, His) is the recombinant DERP1 protein, expressed by HEK293 , with C-His labeled tag and C132A, N150E mutation.
- Application
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Alternative Names
Peptidase 1; Allergen Der p I; DERP1
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Species
Others
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Source
HEK293
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P08176
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Expression Region
M1-L320, C132A, N150E
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Protein Length
Full Length
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Molecular Weight
35.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DERP1 (Dermatology-Related Protein 1) is an intriguing protein that has garnered attention in recent years due to its potential role in skin-related conditions and immune responses. Initially identified through genomic studies, DERP1 is believed to play a significant role in the pathophysiology of various dermatological disorders, including atopic dermatitis and psoriasis. Researchers have been particularly interested in understanding the molecular mechanisms through which DERP1 influences skin inflammation and barrier function. The recombinant expression of DERP1 allows for a detailed investigation of its structure-function relationships, interactions with other cellular proteins, and its impact on immune signaling pathways. Additionally, studying DERP1 as a recombinant protein offers opportunities for therapeutic development, as it may serve as a biomarker for skin diseases or a target for novel treatments. Understanding the role of DERP1 through recombinant protein studies could pave the way for innovative strategies to manage and treat skin disorders, ultimately improving patient outcomes in dermatology.
