Analytical Data
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Gene name
FSTL5
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简介
FSTL5 is an extracellular matrix-secreted protein. FSTL5 promotes cell proliferation and survival by influencing the Wnt/β-catenin signaling pathway in liver cancer and inhibits the progression of liver cancer by inducing Caspase-dependent apoptosis and regulating Bcl-2 family proteins. FSTL5 Protein, Human (HEK293, Fc) is the recombinant human-derived FSTL5 protein, expressed by HEK293 , with C-hFc labeled tag.
- Application
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Alternative Names
Follistatin-related protein 5; Follistatin-like protein 5; KIAA1263
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Species
Human
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Source
HEK293
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Tag
C-hFc
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N475-1
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Expression Region
R21-A847
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Protein Length
Full Length of Isoform-1 Mature Protein
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Molecular Weight
118 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FSTL5 (Follistatin-like 5) is a secreted glycoprotein that plays crucial roles in various physiological and pathological processes, including muscle development, tissue repair, and inflammation. Research has shown that FSTL5 is involved in the regulation of myogenesis and has potential implications in muscle degenerative diseases. Additionally, it has been implicated in the modulation of metabolic processes and the protective responses of various tissues to stress. The study of recombinant FSTL5 protein has garnered interest due to its therapeutic potential in regenerative medicine and obesity-related disorders. Understanding the structure and function of FSTL5 at the molecular level can provide insights into its biological activities and interactions with other signaling pathways, potentially leading to novel treatment strategies. The increasing prevalence of muscle-wasting conditions and metabolic syndromes has further motivated researchers to explore the role of FSTL5 in these contexts. Recent advances in biotechnology have facilitated the production of recombinant FSTL5, allowing for detailed studies of its mechanism of action and effects in various cell types. This research is essential for elucidating the full spectrum of FSTL5's effects on health and disease, paving the way for innovative therapeutic approaches that harness its protective and regenerative capabilities.
