Analytical Data
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Gene name
GNG13
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简介
GNG13 protein, a member of the G protein family, is crucial in diverse transmembrane signaling systems, serving as a modulator or transducer. Its beta and gamma chains within the G protein structure facilitate GTPase activity, enabling GDP-GTP exchange and mediating interactions with effectors. G proteins, with three subunits—alpha, beta, and gamma—work together to regulate and transduce signals across cell membranes. GNG13 Protein, Human (His) is the recombinant human-derived GNG13 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P2W3
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Expression Region
M1-C64
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Protein Length
Partial
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Molecular Weight
9 kDa & 18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GNG13, a member of the guanine nucleotide-binding protein (G protein) family, plays a critical role in cellular signaling pathways, particularly those related to signal transduction. It is involved in the regulation of diverse physiological processes, including cell proliferation, differentiation, and metabolism. Research on GNG13 has gained momentum due to its potential implications in various diseases, such as cancer and metabolic disorders. Understanding the structure and function of the GNG13 recombinant protein is vital for elucidating its mechanisms of action and interactions within the cell. Scientists utilize recombinant DNA technology to produce GNG13 in various systems, enabling detailed studies of its biochemical properties, binding affinities, and downstream signaling effects. These studies contribute to a deeper comprehension of GNG13's role in health and disease, offering insights that may lead to novel therapeutic strategies targeting dysregulated G protein signaling pathways. As the field progresses, continued investigation into GNG13's functional dynamics and interplay with other cellular components remains essential for uncovering its full biological significance.
