Analytical Data
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Gene name
EXOSC5
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简介
EXOSC5 is a non-catalytic RNA exosome complex component that is critical in 3'->5' exoribonuclease activity and affects a variety of cellular RNA processing and degradation processes. In the nucleus, it contributes to stable RNA maturation, byproduct elimination, and noncoding transcript degradation. EXOSC5 Protein, Human is the recombinant human-derived EXOSC5 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
EXOSC5; Exosome complex component RRP46; Chronic myelogenous leukemia tumor antigen 28; Exosome component 5; Ribosomal RNA-processing protein 46; p12B
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQT4
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Expression Region
M1-S235
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EXOSC5, a crucial component of the exonuclease complex, plays a significant role in RNA processing and degradation, influencing various cellular processes such as gene expression, development, and response to stress. Mutations in the EXOSC5 gene have been implicated in diseases like pontocerebellar hypoplasia, underscoring its importance in neurological functions. Given its vital role in maintaining RNA stability and integrity, researchers are increasingly focused on studying EXOSC5 through recombinant protein techniques. These studies aim to elucidate its structural characteristics, functional mechanisms, and interactions with other cellular factors. By producing recombinant EXOSC5, scientists can investigate its enzymatic activity, determine its role in RNA metabolism, and explore its potential as a therapeutic target. Understanding the exact function of EXOSC5 could provide insights into RNA-related disorders and contribute to the development of novel molecular therapies, making it a key focus in molecular biology and biomedicine.
