Analytical Data
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Gene name
EXOSC8
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简介
EXOSC8 is a non-catalytic RNA exosome complex component that is critical for 3'->5' exoribonuclease activity and affects a variety of cellular RNA processing and degradation. In the nucleus, it helps stabilize the maturation of RNA species and eliminates processing by-products, non-coding transcripts and defective mRNAs, thereby preventing their export to the cytoplasm. EXOSC8 Protein, Human is the recombinant human-derived EXOSC8 protein, expressed by E. coli , with tag free.
- Application
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Alternative Names
EXOSC8; Exosome complex component RRP43; Exosome component 8; Opa-interacting protein 2; OIP-2; Ribosomal RNA-processing protein 43; p9
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Species
Human
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Source
E. coli
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96B26
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Expression Region
M1-K276
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Protein Length
Full Length
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
EXOSC8, a core component of the RNA exosome complex, plays a crucial role in RNA processing and degradation, influencing gene expression and maintaining RNA homeostasis within cells. The exosome complex is essential for the efficient turnover of various RNA species, including mRNA, rRNA, and non-coding RNAs, thus contributing significantly to post-transcriptional regulation. Recent studies have highlighted the involvement of EXOSC8 in various cellular processes, including response to stress and cell differentiation, as well as its potential links to several diseases, such as cancer and neurodegenerative disorders. Its importance in the regulation of RNA stability and the quality control of RNA molecules underscores the need for detailed studies on EXOSC8's structure and function. Additionally, the production of recombinant EXOSC8 protein allows researchers to investigate its biochemical properties, interactions with other components of the exosome complex, and its role in RNA metabolism more thoroughly. Understanding the molecular mechanisms mediated by EXOSC8 could provide insights into therapeutic targets for diseases associated with dysregulation of RNA metabolism, making it a significant focus of ongoing research in molecular biology and genetics. Overall, the study of EXOSC8 and its functions is pivotal for elucidating the complex landscape of RNA biology and its implications in health and disease.
