Analytical Data
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基因名
MRE11A
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简介
The MRE11A protein is an important component of the DNA double-strand break repair mechanism and participates in the homologous recombination (HR) pathway. It interacts with RAD50 and NBS1 to form the MRN complex, which is essential for sensing and repairing DNA damage. MRE11A Protein, Human (His, GST) is the recombinant human-derived MRE11A protein, expressed by E. coli , with N-6*His, N-GST labeled tag.
- Application
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别名
MRE11; Double-strand break repair protein MRE11; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A
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种属
Human
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表达系统
E. coli
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标签
N-6*His;N-GST
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P49959
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表达区间
M1-E411
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蛋白长度
Partial
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分子量
74.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRE11A, a critical component of the MRN (MRE11-RAD50-NBS1) complex, plays a vital role in the cellular response to DNA damage, particularly in the repair of double-strand breaks (DSBs). This protein possesses both exonuclease and endonuclease activities, allowing it to process DNA ends during repair processes such as homologous recombination and non-homologous end joining. Research on MRE11A has gained significant attention due to its implications in genomic stability, cancer biology, and various genetic disorders. Mutations or dysregulation of MRE11A are linked to increased susceptibility to cancers, including breast and prostate cancers, along with neurodegenerative diseases. Moreover, its involvement in the DNA damage response pathways makes it a promising target for therapeutic strategies aimed at enhancing the efficacy of radiotherapy and chemotherapy. Studies have also shown that MRE11A is crucial for telomere maintenance, further highlighting its importance in cellular longevity and aging processes. Understanding the functional dynamics of MRE11A at the molecular level could yield insights not only into its role in disease pathogenesis but also into potential biomarkers for cancer prognosis and treatment outcomes. Recent advances in structural biology and biochemistry have facilitated in-depth investigations into the interactions of MRE11A with other proteins and DNA substrates, paving the way for novel research into its regulatory mechanisms and potential applications in gene therapy and precision medicine. This multifaceted role of MRE11A underscores its significance as a focal point for research into DNA repair and cancer therapies, making it an important subject of ongoing scientific inquiry.
