Analytical Data
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Gene name
ST6GALNAC2
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简介
ST6GALNAC2 Protein, an enzyme, is involved in the process of glycosylation.It adds a specific sugar molecule to proteins and lipids, influencing their functions in cell signaling and adhesion.ST6GALNAC2 Protein is also implicated in certain diseases and may serve as a potential target for therapeutic interventions.ST6GALNAC2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ST6GALNAC2 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase,GalNAc alpha-2,6-sialyltransferase II,ST6GalNAc II,Sialyltransferase 7B,SIAT7-B
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Species
Mouse
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P70277
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Expression Region
S28-R373
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AA Sequence
SAGQQSPETQVPARNMAYPRAFFDPKPPNSENRKSRLCQHSLSLAIQKDRRFRSLFDLSTPVLLWEGLFTQELWNNLSQHKVPYGWQGLSHEVIASTLRLLKSPESGELFGAPRKLPLSCIRCAVVGNGGILNGSRQGQKIDAHDYVFRLNGAITEGFERDVGTKTSFYGFTVNTMKNSLISYAKLGFTSVPQGQNLRYIFIPSSIRDYLMLRSAILGVPVPEGPDKGDRPHTYFGPETSASKFKLLHPDFISYLTERFLKSKLINTRFGDMYMPSTGALMLLTALHTCDQVSAYGFITNNYQKYSDHYFEREKKPLIFYANHDLSLEASLWRDLHNAGILWLYQR
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Protein Length
Lumenal Domain
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Molecular Weight
45 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ST6GALNAC2, a member of the ST6Gal family of glycosyltransferases, plays a crucial role in the biosynthesis of glycan structures on glycoproteins and glycolipids. This enzyme specifically transfers sialic acid to N-acetylgalactosamine (GalNAc) residues, resulting in the formation of complex sialylated structures that are vital for various biological processes, including cell-cell interactions, signal transduction, and immune response modulation. Aberrant expression of ST6GALNAC2 has been implicated in several pathological conditions, including cancer, where alterations in glycosylation patterns can influence tumor progression and metastasis. Furthermore, understanding the functional properties of ST6GALNAC2 can provide insights into its potential as a therapeutic target, as well as its involvement in diseases characterized by altered glycosylation. Recent advancements in recombinant protein technologies have enabled the production and characterization of ST6GALNAC2, allowing researchers to investigate its enzymatic activity, substrate specificity, and regulatory mechanisms. These studies are pivotal for elucidating the role of sialylated glycans in health and disease, thereby laying the groundwork for future explorations of glycosyltransferases in clinical applications.
