Analytical Data
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Gene name
NELL2
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简介
NELL2 protein, crucial for neuron survival, modulates MAPK pathways and regulates hypothalamic gonadotropin-releasing hormone (GNRH) secretion, impacting puberty control. NELL2 forms homotrimers and engages with PKC beta-1, indicating intricate molecular interactions in its regulatory functions. NELL2 Protein, Human (sf9, His) is the recombinant human-derived NELL2 protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Application
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Alternative Names
Protein kinase C-binding protein NELL2; NEL-like protein 2; NELL2; NRP2
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Species
Human
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Source
Baculovirus
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Tag
C-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99435
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Expression Region
L22-L816
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Protein Length
Full Length of Mature Protein
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Molecular Weight
110 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NELL2 (Neural EGF-like protein 2) is a member of the epidermal growth factor (EGF) family that plays a crucial role in neural development, survival, and regeneration. Studies have shown that NELL2 is involved in various physiological processes, including neuronal differentiation and neurite outgrowth, making it an attractive target for research in neurodegenerative diseases and injury-related neural repair. The recombinant expression of NELL2 protein has allowed researchers to investigate its structural and functional properties more closely, facilitating the exploration of its signaling pathways and interactions with other proteins. Understanding the mechanisms by which NELL2 influences neuronal health could provide insights into potential therapeutic strategies for conditions such as Alzheimer's disease, Parkinson's disease, and spinal cord injuries. With advances in recombinant DNA technology and protein engineering, producing NELL2 as a functional protein has become increasingly feasible, enhancing our ability to study its biological relevance and therapeutic potential. These studies are crucial for elucidating the molecular underpinnings of neural plasticity and regeneration, ultimately contributing to the development of novel intervention strategies aimed at improving recovery from neural damage.
