Analytical Data
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基因名
BLOC1S2
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简介
BLOC1S2 is an essential component of the BLOC-1 complex and is critical for the biogenesis of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. BLOC-1 cooperates with the AP-3 complex to direct membrane protein cargo into vesicles for delivery to neurites and nerve terminals, suggesting that it is involved in neurite extension. BLOC1S2 Protein, Human (GST) is the recombinant human-derived BLOC1S2 protein, expressed by E. coli , with no tagged.
- Application
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别名
Biogenesis of lysosome-related organelles complex 1 subunit 2; BLOC-1 subunit 2; BLOS2; CEAP
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种属
Human
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表达系统
E. coli
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标签
Tag Free
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6QNY1-2
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表达区间
M1-R99
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蛋白长度
Full Length of Isoform-2
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分子量
11.35 kDa.
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BLOC1S2, a crucial component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1), plays a significant role in cellular processes associated with the trafficking of proteins and lipids to lysosome-related organelles. Mutations in the BLOC1S2 gene are linked to a subset of Hermansky-Pudlak Syndrome (HPS), a genetic disorder characterized by oculocutaneous albinism, bleeding tendencies, and pulmonary fibrosis. The understanding of BLOC1S2's structure and function is vital for unraveling the molecular mechanisms underlying these disorders. Recent studies have highlighted the protein’s involvement in cellular transport mechanisms and its interaction with other proteins within the BLOC-1 complex. Investigating BLOC1S2 not only enhances our knowledge of lysosomal function and organelle biogenesis but also has potential implications for developing therapeutic strategies for HPS and related diseases. Understanding the role of BLOC1S2 in pathophysiology can provide insights into broader cellular dysfunctions and may lead to targeted interventions that restore normal trafficking processes in affected cells. This research is, therefore, pivotal in bridging basic biological insights with clinical applications, aiming to ameliorate the quality of life for individuals affected by such genetic disorders.
