Analytical Data
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基因名
ACSS1
- Application
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别名
ACAS2L; AceCS2L; Acetyl-Coenzyme A Synthetase 2(AMP Forming)-Like; Acetate--CoA ligase 2; Acetyl-coenzyme A synthetase 2-like, mitochondrial
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NUB1
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表达区间
Phe517~Lys689
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分子量
27kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACSS1 (Acetyl-CoA Synthetase 1) is a key enzyme involved in the conversion of acetate into acetyl-CoA, a central metabolite in cellular energy metabolism and biosynthetic pathways. Recent studies have highlighted the significance of ACSS1 in various physiological processes, including fatty acid synthesis, energy homeostasis, and tumorigenesis. Dysregulation of ACSS1 has been implicated in metabolic disorders, such as obesity and diabetes, as well as in cancer progression by providing acetyl-CoA for biosynthetic demands of rapidly proliferating cells. Given its pivotal role, ACSS1 has garnered attention as a potential therapeutic target. Research has focused on understanding its structure, function, and regulatory mechanisms, with the aim of developing inhibitors that could modulate its activity for clinical applications. Furthermore, recent advancements in recombinant protein technology have enabled the production of ACSS1 to facilitate detailed biochemical and structural studies. Investigating the recombinant ACSS1 protein will not only enhance our understanding of its biochemical properties and interactions but also pave the way for novel strategies in the treatment of metabolic diseases and cancer. Overall, the study of ACSS1 is a promising area of research that bridges basic science and therapeutic development, with the potential to significantly impact public health.
