Analytical Data
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Gene name
RNF41
- Application
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Alternative Names
RING finger protein 41
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H4P4
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Expression Region
1-317aa
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Molecular Weight
62.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RNF41 (RING Finger Protein 41) is an E3 ubiquitin ligase that plays a pivotal role in various cellular processes, including protein degradation, signal transduction, and cell cycle regulation. Recent studies have highlighted its involvement in the modulation of immune responses and its potential as a therapeutic target in cancer treatment. Given its significant role in the ubiquitin-proteasome system, RNF41 is crucial for maintaining cellular homeostasis and influencing the stability of key regulatory proteins. The abnormal expression or dysfunction of RNF41 has been linked to various diseases, including malignancies and autoimmune disorders. As researchers strive to elucidate the molecular mechanisms underlying these associations, the recombinant production of RNF41 protein has gained attention, enabling detailed structural and functional analyses. By using advanced techniques such as CRISPR/Cas9, researchers can investigate RNF41's mechanistic pathways, its interactions with substrates, and the subsequent impact on cellular functions. Understanding RNF41's role could pave the way for novel therapeutic strategies, particularly in contexts where its regulatory functions are compromised. Thus, the characterization of RNF41 through recombinant protein expression serves as a critical foundation for subsequent investigations into its biological significance and potential clinical applications.
