Analytical Data
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Gene name
NR1D2
- Application
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Alternative Names
HZF2; BD73; EAR-1r; RVR; Rev-ErbA Beta; Orphan nuclear hormone receptor BD73; Rev-erb alpha-related receptor; V-erbA-related protein 1-related
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Species
Rat
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q63504
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Expression Region
Lys249~Pro578
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Molecular Weight
67kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NR1D2 (Nuclear Receptor Subfamily 1 Group D Member 2), also known as Rev-Erbβ, is a member of the nuclear receptor superfamily that plays a critical role in various biological processes, including circadian rhythms, metabolism, and immune response. Research on NR1D2 has gained traction due to its pivotal function in regulating gene expression and mediating the effects of hormones and metabolic signals. NR1D2 acts as a transcriptional repressor for several target genes, influencing the expression of proteins involved in lipid metabolism and inflammatory responses. The dysregulation of NR1D2 is implicated in a range of diseases, including obesity, diabetes, and cardiovascular disorders, making it a potential therapeutic target. Furthermore, its role in circadian biology highlights the importance of time-of-day in physiological processes and suggests that manipulating NR1D2 activity could lead to novel chronobiological therapies. Protein engineering and recombinant protein studies of NR1D2 provide insights into its functional mechanisms and interactions, paving the way for better understanding its role in health and disease. Overall, the study of NR1D2 and its recombinant protein forms holds promise for elucidating its complex regulatory networks and developing new strategies for managing metabolic and circadian-related disorders.
