Analytical Data
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基因名
PCDH18
- Application
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别名
PCDH68L
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8VHR0
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表达区间
Phe378~Asp607
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分子量
29kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDH18, a member of the protocadherin family, plays a crucial role in cell-cell adhesion and signaling in the nervous system. Emerging research has highlighted its significance in neurodevelopment and potential implications in various neuropsychiatric disorders due to its involvement in synaptic formation and plasticity. Structurally, PCDH18 is characterized by multiple extracellular cadherin domains that facilitate homophilic interactions, critical for maintaining cellular architecture and communication in neuronal tissues. Studies investigating the recombinant expression of PCDH18 have aimed to elucidate its functional properties and interactions with other neuronal proteins, shedding light on its mechanisms in synaptic dynamics. Furthermore, understanding the role of PCDH18 in pathological conditions can pave the way for novel therapeutic strategies. The recombinant protein serves as a valuable tool for exploring these interactions in vitro, providing insights into how disruptions in PCDH18 may contribute to the etiology of disorders like schizophrenia and autism spectrum disorders. Overall, the research on PCDH18 recombinant protein not only advances our understanding of fundamental neuronal processes but also holds promise for translational applications in neurobiology.
