Analytical Data
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Gene name
PCDH20
- Application
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Alternative Names
PCDH13; Protocadherin-13
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N6Y1
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Expression Region
Arg64~Phe209
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Molecular Weight
19kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDH20, a member of the protocadherin family, is an important cell adhesion molecule that plays a critical role in neuronal development and function. Its expression is predominantly observed in the central nervous system, where it is believed to contribute to synaptic plasticity and the establishment of neuronal networks. Recent studies have suggested that alterations in PCDH20 expression may be associated with various neurological disorders, including autism spectrum disorders and schizophrenia, highlighting its potential as a biomarker or therapeutic target. The recombinant PCDH20 protein has been utilized to investigate its structural features and functional roles further. By expressing PCDH20 in heterologous systems, researchers can analyze its adhesion properties, interaction with other proteins, and implications in cellular signaling pathways. Understanding the molecular mechanisms of PCDH20's function is crucial for uncovering its contributions to both normal neurodevelopment and the pathogenesis of neurological diseases. These insights may pave the way for novel strategies in treating such disorders through modulation of PCDH20's activity or its signaling pathways. As the emphasis on precision medicine grows, exploring the role of PCDH20 in neurodevelopmental processes could offer new avenues for therapeutic interventions and enhance our understanding of complex neurobiological phenomena.
