Analytical Data
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Gene name
SHC3
- Application
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Alternative Names
N-Shc; NSHC; SHCC; Neuronal Shc; Protein Rai; SHC-transforming protein C; Src homology 2 domain-containing-transforming protein C3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92529
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Expression Region
Val188~Gln433
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Molecular Weight
57.0kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SHC3 (Src Homology 2 domain-containing protein C3) is a member of the SHC family of adapter proteins, which play a crucial role in signal transduction pathways involved in cellular growth, differentiation, and metabolism. Research on SHC3 has gained interest due to its potential involvement in various physiological processes and pathological conditions, including cancer and metabolic disorders. Recent studies suggest that SHC3 may facilitate the transmission of signals from activated receptors to downstream effector pathways, thereby influencing cell survival and proliferation. Additionally, alterations in SHC3 expression and function have been linked to certain cancers, prompting investigations into its role as a biomarker for diagnosis or therapeutic target. The recombinant production of SHC3 protein has become pivotal for studying its biological functions, structure-function relationships, and interactions with other signaling molecules. To this end, various expression systems, such as bacterial, yeast, and mammalian cells, have been explored to generate functional SHC3 protein. Detailed analysis of SHC3's mechanisms of action and its interactions with other signaling pathways will enhance our understanding of its role in health and disease, potentially leading to novel therapeutic strategies. Given the complexity of intracellular signaling networks, further research is warranted to elucidate the full spectrum of SHC3's biological activities and its relevance in clinical settings.
