Analytical Data
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Gene name
KPNa4
- Application
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Alternative Names
IPOA3; QIP1; SRP3; Importin Alpha 3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00629
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Expression Region
Ala2~Phe521
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Molecular Weight
88kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KPNa4, a member of the karyopherin family, is involved in the nuclear transport process, specifically in the translocation of proteins between the cytoplasm and the nucleus. Understanding the mechanisms of nuclear transport is crucial, as it plays a vital role in various cellular functions, including gene expression, cell division, and response to environmental signals. The study of KPNa4 is particularly important due to its potential implications in various diseases, including cancer, where misregulation of nuclear transport can lead to abnormal cellular behavior. Recent research has shown that KPNa4 may influence the localization of key regulatory proteins within the nucleus, thereby impacting cellular signaling pathways. Researchers are keen to explore the structural properties and functions of KPNa4, aiming to elucidate its role in the transport of specific cargo proteins and its interaction with other nuclear transport receptors. Investigations into KPNa4 could provide insights into novel therapeutic strategies for diseases associated with nuclear transport dysregulation, highlighting its significance in the field of cellular biology and medicine.
