Analytical Data
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基因名
IPO4
- Application
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别名
Imp4; RanBP4; IMP4B; Ran-binding protein 4
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8VI75
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表达区间
Met1~Arg189
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分子量
25kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
IPO4 (Importin 4) is a member of the importin family of proteins that play a crucial role in the nuclear transport of proteins and other macromolecules. It is primarily involved in the import of various cargoes, including transcription factors and signaling proteins, into the nucleus, thereby impacting gene expression and cellular function. Recent research has highlighted the importance of IPO4 in various physiological and pathological processes, including cell proliferation, differentiation, and response to stress. Abnormalities in nuclear transport mechanisms, including those involving IPO4, have been linked to several diseases, including cancer and neurodegenerative disorders. Given its significant role in the nuclear import pathways, IPO4 has garnered attention as a potential target for therapeutic interventions. The study of IPO4 recombinant protein focuses on elucidating its structure, function, and interaction with various cargo molecules, as well as the regulatory mechanisms that govern its activity. By producing IPO4 as a recombinant protein, researchers can investigate its biochemical properties and delineate its role in cellular processes, paving the way for novel therapeutic strategies that leverage its function in nuclear transport. This research is critical for understanding the broader implications of nuclear transport in health and disease, as well as the development of drugs that can modulate these pathways for therapeutic benefit.












