Analytical Data
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Gene name
KPNa6
- Application
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Alternative Names
IPOA7; KPNA7; Importin Alpha 7
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60684
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Expression Region
Met1~Thr410
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Molecular Weight
48kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KPNa6, a member of the karyopherin family, plays a critical role in nucleocytoplasmic transport, specifically in the transport of proteins and RNA across the nuclear envelope. It is known to recognize and bind to nuclear localization signals (NLS) on cargo proteins, facilitating their import into the nucleus. Recent studies have highlighted the importance of KPNa6 in various biological processes, including cell cycle regulation and signal transduction, as well as its implications in diseases such as cancer and viral infections. Furthermore, the overexpression or dysregulation of KPNa6 has been linked to tumorigenesis and poor prognosis in several cancer types, underscoring its potential as a therapeutic target. Additionally, KPNa6 interacts with numerous cellular proteins, suggesting that it plays a multifaceted role in cellular homeostasis and response to stress. Understanding the molecular mechanisms governing KPNa6 function and its interactions with other nuclear transport receptors could provide insights into its regulatory pathways and open new avenues for targeted therapeutics in diseases associated with aberrant nucleocytoplasmic transport. As research advances, KPNa6 is emerging as a significant focus within the field of molecular biology, driving investigations into its various roles in health and disease and its potential as a biomarker and therapeutic target.
