Analytical Data
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Gene name
GRIN2B
- Application
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Alternative Names
NMDAR2B; NR2B; hNR3; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13224
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Expression Region
Ile35~Asp557
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Molecular Weight
89kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GRIN2B encodes one of the key subunits of the NMDA (N-methyl-D-aspartate) receptor, a crucial component of the glutamatergic neurotransmission system in the brain. This receptor plays a vital role in synaptic plasticity, learning, and memory processes. Mutations in the GRIN2B gene have been linked to various neurodevelopmental disorders, including intellectual disability, autism spectrum disorders, and epilepsy, highlighting its significance in brain development and function. Recombinant GRIN2B proteins are essential for studying the structure-function relationships of NMDA receptors and understanding their role in synaptic signaling. By producing and characterizing these proteins, researchers can investigate the effects of specific mutations, drug interactions, and the receptor's physiological mechanisms. Furthermore, recombinant GRIN2B proteins serve as valuable tools for high-throughput screening of potential therapeutics aimed at modulating NMDA receptor activity in disease contexts. Such studies can lead to new insights into neuropsychiatric conditions and guide the development of targeted treatments, making GRIN2B an important focus in neuroscience research.
