Analytical Data
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Gene name
ITPR2
- Application
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Alternative Names
IP3R2; IP3 receptor isoform 2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14571
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Expression Region
Met1~Val287
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Molecular Weight
38kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ITPR2, or Inositol 1,4,5-trisphosphate receptor type 2, is a protein that plays a crucial role in intracellular calcium signaling, which is essential for various physiological processes, including muscle contraction, neurotransmitter release, and cell proliferation. Research has shown that ITPR2 is involved in several diseases, including cancer and neurodegenerative disorders, where dysregulation of calcium signaling can lead to pathological conditions. In the context of cancer, altered expression levels of ITPR2 have been linked to tumor progression and poor prognosis, making it a potential biomarker for therapeutic intervention. Moreover, understanding the structure and function of ITPR2 can provide insights into the mechanisms of calcium signaling and its implications in health and disease. Advances in recombinant protein technology have enabled the production of ITPR2 for detailed structural and functional studies, including characterization of its ligand binding and ion channel activity. This research aims to elucidate the role of ITPR2 in cellular signaling pathways and explore its potential as a therapeutic target, ultimately contributing to the development of new strategies for the treatment of diseases associated with calcium signaling dysregulation.
