Analytical Data
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基因名
GRIN2D
- Application
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别名
EB11; NMDAR2D; NR2D; N-Methyl-d-Aspartate Receptor Subunit 2D; Glutamate [NMDA] receptor subunit epsilon-4
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15399
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表达区间
Phe28~Ala584
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分子量
64kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GRIN2D gene encodes for a subunit of the NMDA receptor, a critical player in synaptic plasticity and neurotransmission in the central nervous system. Recent research highlights the importance of NMDA receptors in various neurological disorders, such as schizophrenia, Alzheimer's disease, and epilepsy, making GRIN2D an intriguing target for therapeutic intervention. Despite its significance, the functional properties and molecular mechanisms of the GRIN2D subunit remain poorly understood compared to its well-studied counterparts. To address this gap, researchers have turned to the production of recombinant GRIN2D proteins to facilitate in-depth studies of its pharmacological characteristics, protein interactions, and role in receptor assembly and function. Utilizing advanced techniques in recombinant DNA technology, scientists aim to express and purify GRIN2D proteins for structural and functional analyses. Such studies are essential for elucidating the nuances of NMDA receptor signaling and for developing targeted therapies that could ameliorate the effects of disorders linked to dysfunctional GRIN2D pathways. As research progresses, a deeper understanding of GRIN2D's role in neurobiology may uncover new avenues for drug discovery and therapeutic strategies.
